Item #: CASE NO: 045
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Description 

OBJECT:
Dispersion of isotretinoin in oil/gelatin dosage form.
PROBLEM:
Pre-disperse 100 micron crystals of isotretinoin prior to final fine grinding and incorporation into dosage form.
RESULTS:
Reversible homogenizing mixer is able to effectively prepare a pre-dispersion that optimizes the subsequent processing with a liquid jet micronizer.
AB MIXER:
Model CJ-4C Reversible Homogenizer