Pharmaceutical

DRUG CAPSULES

Description
OBJECT: White pharmaceutical capsules. Two steps: (a) Disperse water dispersible Titanium Dioxide into water at 50% solids, 49% water and 1% wetting agent. (b) Disperse above mix into heated gelatin/water solution.
PROBLEM: Provide excellent dispersion for full color development without breaking gel.

RESULT: (a) Placed mixer in water and operated in down-mode. Added wetting agent, then TiO2 to vortex to prewet and predisperse. Next, ran mixer in up-mode for 15 minutes.

(b) Dissolve gelatin in warm water. Must maintain temperature above 55 deg. C or gelatin will solidify. Place mixer into gelatin/water solution. Operate in down-mode and add TiO2 dispersion into vortex. Then operate mixer in up-mode until final dispersion is achieved. NEVER add gelatin to TiO2 solution. Above 50% TiO2 will cause flocculation.

AB MIXER: SOLD C-1, 33″ immersion, 3-7/8″ rotor, 5 HP motor.

Product Lines Used in this Case